Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.8, sa.3, ss.309-312, 1997 (SCI-Expanded)
In this study, which was held in relation with the former one, the aim was to ascertain the primary resistance of Helicobacter pylori (H. pylori) isolates to clarithromycin and amoxicillin as well as to compare it with resistance in recurrent cases after combination therapies. Gastroduodenoscopy was performed in 61 patient (35 men; 26 women) with different dyspeptic complaints and antral biopsies were obtained and cultured for H. pylori. Primary resistance was evaluated by disc diffusion method and zone radius of 15 mm or greater was accepted as susceptible whereas 11 mm or lesser measures were accepted as resistant. This group was treated with omeprazole (2x20 mg/day) + clarithromycin (3x500 mg/day) for 2 weeks and then recurrent cases were re-evaluated for secondary resistance recording. Second group of 51 patients (32 men; 19 women) were investigated by the same method for omeprazole (2x20 mg/day) + amoxicillin (2x1 gr/day) recording the differences in susceptibility. As no primary resistance was seen in clarithromycin group, two isolates (3.2 %) were found resistant after treatment (secondary resistance). On the other hand, neither primary nor secondary resistance was recorded for amoxicillin. In conclusion, we think that administration of both drugs in combination will fulfill an effective and safe treatment of H. pylori of which resistance emerges as an important clinical problem.