Fe3O4 magnetic nanoparticles-loaded thermoresponsive poly(N-vinylcaprolactam)-g-galactosylated chitosan microparticles: investigation of physicochemical, morphological and magnetic properties

DURKUT S.

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, cilt.60, sa.3, ss.181-191, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/10601325.2023.2185530
  • Dergi Adı: JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.181-191
  • Anahtar Kelimeler: Thermosensitive polymer, magnetic nanoparticles, iron oxide nanoparticles, hybrid hydrogel, suspension crosslinking, biocompatibility, IRON-OXIDE NANOPARTICLES, DRUG-DELIVERY, HYDROGELS, GLUTARALDEHYDE, MICROSPHERES, HYPERTHERMIA, CARRIER
  • Ankara Üniversitesi Adresli: Evet

Özet

A novel thermoresponsive magnetic hydrogel microparticle system was obtained by magnetic nanoparticles (MNPs) combined with poly(N-vinylcaprolactam)-g-galactosylated chitosan (GC) (PNVCL-g-GC) hybrid hydrogel. Fe3O4@PNVCL-g-GC microparticles (MPs) were synthesized by the suspension crosslinking method and the Fe3O4 MNPs were successfully encapsulated in the hybrid hydrogel with good magnetism. Fe3O4@PNVCL-g-GC MPs were characterized by ATR-FTIR, LCST, SEM-EDAX, particle size, zeta potential, TGA and VSM analyses. The size distribution of the spherical Fe3O4@PNVCL-g-GC MPs at room temperature was in the range of 390-530 nm, while it was measured as similar to 220-340 nm above the LCST. The cytocompatibility and hemocompatibility of the Fe3O4@PNVCL-g-GC MPs were confirmed by in vitro ISO analyses. In conclusion, biocompatible, temperature- and magnetic-responsive small-size Fe3O4@PNVCL-g-GC MPs with enhanced mechanical stability were developed which could have the potential for a variety of biomedical applications such as controlled release systems, in situ bioactive agents carrier, and anti-cancer therapy in the future.