Akademik Veri Yönetim Sistemi
JOURNAL OF PEDIATRIC INFECTION, sa.1, ss.1-5, 2007 (ESCI)
Aim: To investigate the clinical features and outcome of children with Pseudomonas aeruginosa infections who were followed in our hospital, and determine the antibiotic susceptibilities of isolated P. aeruginosa strains. Material and Methods: The clinical features of the patients with P. aeruginosa infections who were followed at Ankara University Medical School, Department of Pediatrics, between 1994 and 2002 were investigated retrospectively. Antibiotic susceptibilities of isolated P. aerugi-nosa strains were determined by disc diffusion method. Results: One hundred and thirty six P. aeruginosa strains were isolated from 100 patients during the study period. Majority of the P. aeruginosa infections (71%) were hospital acquired. Majority of the patients had at least one underlying condition for infection, such as prematurity, anatomic or functional disorders of urinary tract, and malignancy. The most common clinical diagnoses for P. aeruginosa infection were pneumonia, urinary infections and bacteremia/septicemia. Majority of the infections (90 of 136) were treated with a combined antibacterial therapy, whereas 46 of 136 infections treated with monotherapy. An antipseudomonal beta lactam antibiotic combined with an aminoglicoside was the most common therapy schedule. Twenty-three of 136 patients died in spite of the therapy. Mortality was more common in patients with bacteremia/septicemia. Younger age (< 12 months), disseminated intravascular coagulation and shock were risk factors for mortality in children with bacteremia/septicemia. Antibiotic susceptibilities of isolated 136 P. aeruginosa strains were as follows; ciprofloxacin 98%, imipenem 92%, meropenem 87%, cefoperazon-sulbactam 90%, piperacillin 86%, aztreonam 67%, ceftazidim 60%, amikacin 66%, netilmicin 57%, tobramicin 48%, and gentamicin 44%. Conclusion: Majority of the P. aeruginosa infections were hospital acquired. An underlying condition is commonly present in patients with P. aeruginosa infections. Mortality is higher in patients with bacteremia/septicemia. An antipseudomonal beta lactam antibiotic combined with an aminoglicoside might be recommended for empirical therapy. (J Pediatr Inf 2007; 1: 1-5)