Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.12, sa.1, ss.13-18, 2001 (SCI-Expanded)
Background/aims: Abnormalities of thrombocyte number and function may increase the tendency to bleed in the setting of liver cirrhosis. The aim of this study was to determine the relationship between the stage of liver disease and thrombocyte functions. Methods: A total of 42 cases (23 male, 19 female; with a mean age of 44.8 years) comprising 17 cirrhosis, 15 chronic active hepatitis and 10 healthy control patients were studied. In all cases complete blood counts, bleeding time and prothrombin time and blood chemistries were determined as well as maximum aggregation rate, maximum aggregation severity and adenosine 3 phosphate secretion upon induction with three different agents (adenosine diphosphate, collagen and ristocetin). Results: There was no significant difference between the hepatitis and control group for any parameter. Mean maximum aggregation rate and mean maximum aggregation severity induced by Adenosine diphosphate, collagen and ristocetin and mean adenosine 3 phosphale secretion levels induced by collagen and ristocetin were significantly lower in the cirrhosis group (p<0.05). The decrease in thrombocyte aggregation rate, aggregation severity and adenosine 3 phosphale secretion were found to be independent of thrombocyte number. Conclusions: In the chronic active hepatitis stage of liver disease, functional abnormality of thrombocytes was not detected. In the cirrhotic stage, however, there were significant functional abnormalities although these caused no significant prolongation of bleeding time.