The effect of CD34 count and clonogenic potential of hematopoietic stem cells on engraftment

Sari T., YÜKSEL M., TOPÇUOĞLU P., Tol M., Ayyildiz E., ÖZCAN M., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.43, sa.3, ss.315-320, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.transci.2010.09.020
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.315-320
  • Anahtar Kelimeler: Stem cell transplantation, Colony forming units, Hematological recovery, CD34 (+) cell, PERIPHERAL-BLOOD PROGENITOR, HIGH-DOSE CHEMOTHERAPY, GRANULOCYTE-MACROPHAGE, PLATELET ENGRAFTMENT, BONE-MARROW, CFU-GM, TRANSPLANTATION, IMPACT, RECOVERY, SUBSETS
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study we have determined that the number of the CD34 (+) cells in the grafts that were infused to 48 patients who underwent autologous and allogeneic hematopoietic cell transplantation and evaluated the number of colony forming units in vitro. Our aim was to determine whether there is a relation between these cell counts and post transplantation engraftment kinetics. A negative correlation was detected (p < 0.05) between the CD34 (+) cell count and all colony forming units. A correlation between the CD34 (+) cell count and the kinetics of engraftment could not be demonstrated. In the autologous group, only a weak negative correlation between the CFU-GEMM and neutrophil engraftment was detected. In the allogeneic group, colony forming units did not determine the engraftment. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.