Controlled release behavior of capsaicin from CTAB-modified montmorillonite
Applied Clay Science, cilt.293, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 293
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.clay.2026.108388
- Dergi Adı: Applied Clay Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, Geobase, Index Islamicus, INSPEC, Academic Search Ultimate (EBSCO), Engineering Source (EBSCO)
- Anahtar Kelimeler: Capsaicin, Controlled Release, Drug Loading, Montmorillonite, Organoclay, Release Kinetics
- Ankara Üniversitesi Adresli: Evet
Özet
This study aimed to control capsaicin release from montmorillonite (MMT) to extend its half-life and improve stability in simulated gastric fluid. MMT was beneficiated from bentonite and modified with cetyltrimethylammonium bromide (CTAB) at various concentrations to determine the optimal modification ratio. Based on preliminary characterization, the sample modified with CTAB at 50% of its cation exchange capacity (50% CEC-CTAB) was selected for drug loading. Capsaicin was loaded onto beneficiated MMT (F1) and CTAB-modified MMT (F2). In vitro release tests revealed that F2 significantly retarded the release rate compared to F1 (maximum release of 93.3% at 240 min vs 98.3% at 300 min), exhibiting a controlled release profile consistent with the Higuchi kinetic model. Characterization via XRD, FT-IR, SEM, particle size analysis, and Zeta Potential ( ζ ) confirmed the successful intercalation of surfactant and loading of capsaicin. Preliminary (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT screening using Caco-2 human colorectal adenocarcinoma cells indicated concentration-dependent cytotoxicity, with F2 showing a lower IC50 than blank 50-M-MMT. These findings suggest that CTAB-modified MMT is a promising organoclay-based carrier for the controlled delivery of hydrophobic drugs.