Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study

Kaya C., Cengiz S. D., BERKER B., Demirtaş S., Cesur M., Erdoǧan G.

Fertility and Sterility, cilt.92, sa.2, ss.635-642, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.fertnstert.2008.06.006
  • Dergi Adı: Fertility and Sterility
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.635-642
  • Anahtar Kelimeler: homocysteine, insulin resistance, Polycystic ovary syndrome, statin therapy, testosterone
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: To test the hypothesis that statins improve hyperhomocysteinemia in women with polycystic ovary syndrome (PCOS). Design: A prospective randomized study. Setting: University Hospital. Patient(s): Fifty-two women with PCOS and 52 women matched for age and body mass index as controls. Intervention(s): Patients were randomly divided into two groups for treatment: group 1, atorvastatin, 20 mg daily (n = 26), and group 2, simvastatin, 20 mg daily (n = 26). Blood samples were obtained before and after treatment. Main Outcome Measure(s): Serum homocysteine levels. Result(s): After 12 weeks of treatment, serum homocysteine levels in group 1 had decreased from 14.3 ± 2.9 to 10.6 ± 1.7 μmol/L; in group 2, the levels decreased from 13.6 ± 2.1 to 11.1 ± 1.9 μmol/L. Both two groups, free testosterone and total testosterone declined statistically significantly (38.3% and 36.5%; and 40.6% and 46.0%, respectively). In group 1, vitamin B12 increased from 362.1 ± 107 to 478.7 ± 267 pg/mL; in group 2, it increased from 391.3 ± 107 to 466 ± 211 pg/mL, but the change did not reach statistical significance. There was a considerable decline in the homeostatic model assessment index in group 1 (40.0% to 32.1%). Conclusion(s): Treatment with statins in women with PCOS leads to decreases in serum homocysteine levels. © 2009 American Society for Reproductive Medicine.