Akademik Veri Yönetim Sistemi
Fabad Journal of Pharmaceutical Sciences, cilt.43, sa.1, ss.31-40, 2018 (Scopus)
© 2018 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.Type 2 diabetes is a chronic and complex disease characterized by impaired pancreatic beta cell function and insulin resistance. Several genetic and environmental factors are playing role in the Type 2 diabetes development. Recent studies pointed out a relationship between the inflammation generation and development of the disease. The inflammation induced-activation of the monocytes enhances the insulin resistance and decreases the insulin secretion due to the impairment of the pancreatic beta cells and also oxidative stress occurring after the disorder of the lipid metabolism affects the disease development. Following the oxidative stress formation, the levels of the reactive oxygen species (ROS) increase and insulin resistance develops consequently. Cytokines are the keystones in regulation of the homeostatic mechanisms such as inflammation and tissue repair. Thus, variations in their levels and structures are the reasons for the occurrence of various diseases. The single nucleotide polymorphisms (SNP) forming on the cytokine genes affect the cytokine gene expression levels and increase the risk of the disease development. Recent studies showed that there may be possible relationships between some cytokine gene polymorphisms and the development of type 2 diabetes.