Microarray studies in Bacillus subtilis

Kocabaş P., ÇALIK P., ÇALIK GARCİA G., Özdamar T. H.

Biotechnology Journal, vol.4, no.7, pp.1012-1027, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 4 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1002/biot.200800330
  • Journal Name: Biotechnology Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1012-1027
  • Keywords: Bacillus subtilis, Biomolecule, Genomics, Microarray, Transcriptome
  • Ankara University Affiliated: Yes

Abstract

This review focuses on the construction of a global, comprehensive understanding of Bacillus subtilis through microarray studies. These studies were analyzed regarding growth media, bioreactor operation conditions, RNA isolation method, number of data points analyzed in exponential or stationary phases, compared genotypes, induction and repression ratios, investigated gene(s) and their positive and/or negative influences. Based on the theme and scope of the studies, the articles are reviewed under seven thematic sections: effects of gene deletion(s) or overexpression, effects of overexpression of heterologous genes, comparison of global gene expression between aerobic and anaerobic respiration, effects of temperature change, effects of transported molecules, effects of limitations and stress conditions, and other microarray studies in B. subtilis. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.