The spectrophotometric multicomponent analysis of a ternary mixture of ascorbic acid, acetylsalicylic acid and paracetamol by the double divisor-ratio spectra derivative and ratio spectra-zero crossing methods

DİNÇ E.

TALANTA, vol.48, no.5, pp.1145-1157, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 5
  • Publication Date: 1999
  • Doi Number: 10.1016/s0039-9140(98)00337-3
  • Journal Name: TALANTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1145-1157
  • Keywords: double divisor-ratio spectra derivative and ratio spectra-zero crossing methods, ascorbic acid, acetylsalicylic acid, paracetamol, ACETAMINOPHEN, RESOLUTION, CAFFEINE, HYDROCHLORIDE, PRODUCTS
  • Ankara University Affiliated: Yes

Abstract

The double divisor-ratio spectra derivative and ratio spectra-zero crossing methods were applied to the analysis of an effervescent tablet containing the title compounds without using a chemical separation procedure. In the use of both methods, the calibration graphs were linear in the range of 8-28 mu g ml(-1) for three compounds. Comparison of the results obtained by the two methods indicates that both methods gives the best results. (C) 1999 Elsevier Science B.V. All rights reserved.