Five new nortropane alkaloids and six new amino acids from the fruit of <i>Morus alba</i> LINNE growing in Turkey

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Kusano G., Orihara S., Tsukamoto D., Shibano M., Coskun M., Guvenc A., ...Daha Fazla

CHEMICAL & PHARMACEUTICAL BULLETIN, cilt.50, sa.2, ss.185-192, 2002 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 50 Sayı: 2
• Basım Tarihi: 2002
• Doi Numarası: 10.1248/cpb.50.185
• Dergi Adı: CHEMICAL & PHARMACEUTICAL BULLETIN
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
• Sayfa Sayıları: ss.185-192
• Anahtar Kelimeler: Morus alha, nortropane, pyrrolidinyl dodecanoic acid, piperidinyl dodecanoic acid, structural elucidation, alpha-glucosidase inhibition, GLYCOSIDASE INHIBITORY ACTIVITIES
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Ankara Üniversitesi Adresli: Evet

Özet

Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxy-nortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta,4alpha-trihydroxynortropane (4), 3beta,6exo-dihydroxynortropane (5), (3R)-3-hydroxy-12-{(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yl}-dodecanoic acid-3-O-beta-nu-glucopyranoside (7), (3R)-3-hydroxy-12-{(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yl}-dodecanoic acid (8), (3R)-3-hydroxy-12-[(IR,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid-3-O-beta-D-glucopyranoside (9), (3R)-3-hydroxy-12-[(1,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid (10), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-hydroxymethyl-piperidin-1-yl]-dodecanoic acid-3-O-beta-D-glucopyranoside (11), and (3R)-3-hydroxy-12-[(1R,4S,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid (12) on the basis of spectral and chemical data.