Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex psi

Anadolu R., Sen T., Tarimci N., Birol A., Erdem C.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, vol.18, no.4, pp.416-421, 2004 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1468-3083.2004.00929.x
  • Journal Name: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.416-421
  • Keywords: retinoic acid, cyclodextrin, acne vulgaris, TRETINOIN GEL 0.025-PERCENT, PERCUTANEOUS-ABSORPTION, 0.1-PERCENT, DRUGS, DELIVERY, SKIN
  • Ankara University Affiliated: No

Abstract

Objectives Retinoic acid (RA) has long been used, both topically and systemically, for disorders of keratinization, acne and related disorders. In the present study, the efficacy and tolerability of topical RA prepared as a cyclodextrin beta complex (beta-CD) is investigated in 66 acne vulgaris patients.