First derivative spectrophotometric determination of cefixime and cefdinir in pharmaceutical preparations Sefdinir ve sefiksim'in farmasötik preparatlarda birinci tiirev spektrofotometrik tayini
Turkish Journal of Pharmaceutical Sciences, cilt.10, sa.3, ss.321-328, 2013 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 3
- Basım Tarihi: 2013
- Dergi Adı: Turkish Journal of Pharmaceutical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.321-328
- Anahtar Kelimeler: Cefdinir, Cefixime, First derivative spectrophotometry, Pharmaceutical preparations
- Ankara Üniversitesi Adresli: Evet
Özet
In this study, a first derivative spectrophotometric method was developed for the determination of cefdinir and cefixime in pharmaceutical preparations. Cefdinir and cefixime were dissolved in 0.1 M Na2HPO4 (pH 8.0) and dA/dX values were measured at 306.8 nm for cefdinir and 307.0 nm for cefixime in their first derivative spectra. Cefdinir and cefixime obey Beer's Law in the range of 2-30 μg/mL (r=0.9993) and 2.5-35 μg/mL (r=0.9997) respectively. LOD values were 0.28 μg/mL and 0.45 μg/mL and LOQ values were 0.98 μg/mL and 1.50 μg/mL for cefdinir and cefixime respectively. Method was validated and successfully applied to tablet formulations marketed in Turkey. The results were compared with an previously developed HPLC method.