gamma A gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

Akar N., Sipahi K., Akar E., YILMAZ E.

THALASSEMIA REPORTS, cilt.4, sa.2, ss.65-66, 2014 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.4081/thal.2014.1935
  • Dergi Adı: THALASSEMIA REPORTS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.65-66
  • Anahtar Kelimeler: hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim of this study was to analyze gamma A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe.