Oral Lactoferrin to Prevent Nosocomial Sepsis and Necrotizing Enterocolitis of Premature Neonates and Effect on T-Regulatory Cells
AMERICAN JOURNAL OF PERINATOLOGY, cilt.31, sa.12, ss.1111-1119, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 12
- Basım Tarihi: 2014
- Doi Numarası: 10.1055/s-0034-1371704
- Dergi Adı: AMERICAN JOURNAL OF PERINATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1111-1119
- Anahtar Kelimeler: lactoferrin, VLBW, sepsis, NEC, T-regulatory lymphocytes, BIRTH-WEIGHT INFANTS, HUMAN-MILK, INFECTIONS, SUPPLEMENTATION, TRIAL
- Ankara Üniversitesi Adresli: Evet
Özet
Objective Lactoferrin (LF) is effective in the prevention of sepsis in very low birth weight (VLBW) neonates. T-regulatory cells (Tregs) are important subsets of T lymphocytes that control pathogen-specific immune responses and are essential for intestinal immune homoeostasis. The aim of the present study is to determine whether oral LF at a dosage of 200 mg/d reduces nosocomial sepsis episodes and necrotizing enterocolitis (NEC) in premature infants and to evaluate the possible effects of LF on Treg levels.