beta-Tubulin mRNA Expression Profiles During Long-Term Memory Formation in Classically Conditioned C. Elegans

Erdoğan M., Sahin E.

JOURNAL OF NEUROLOGICAL SCIENCES, vol.30, no.2, pp.296-304, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2013
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.296-304
  • Keywords: C. elegans, learning, memory, long-term memory, classical conditioning, tubulin, NEMATODE CAENORHABDITIS-ELEGANS, GLUTAMATE-RECEPTOR, PROTEIN-SYNTHESIS, APLYSIA, NEURONS, SENSITIZATION, HABITUATION, FACILITATION, CHEMOTAXIS, GENETICS
  • Ankara University Affiliated: Yes

Abstract

We report on the mRNA expression profiles of beta-tubulin genes in Caenorhabditis elegans during the process of classical conditioning, a type of associative learning. In this research, based on the model that suggests the formation of new synaptic connections for long-term memory storage by means of cytoskeletal rearrangement, we measure the expressional changes on the beta-tubulin mRNA levels via quantitative real-time PCR. Using this method, we find that beta-tubulin mRNA levels do not significantly change in C. elegans during classical conditioning and long-term memory formation process.