Enhancing survival after ionizing radiation exposure through mitigation of pyroptosis

Richter B., Epperly M., Tyurina Y., Shurin G., Johnson C., Korkmaz A., ...More

Biochimica et Biophysica Acta - Molecular Basis of Disease, vol.1870, no.7, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1870 Issue: 7
  • Publication Date: 2024
  • Doi Number: 10.1016/j.bbadis.2024.167434
  • Journal Name: Biochimica et Biophysica Acta - Molecular Basis of Disease
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE
  • Keywords: Cell Death, Immunology, Inflammation, Pharmacology, Pyroptosis, Radiation
  • Ankara University Affiliated: No

Abstract

• Pyroptosis is implicated in the pathogenesis of ionizing radiation so we investigated cell type involvement in a mouse model. • Pyroptotic markers were expressed highly at day 3 post total body irradiation (TBI) predominantly in immune cells from ileum. • We investigated the effectiveness of MCC950, a pyroptosis inhibitor, in our model showing survival benefit at 50 mg/kg. • Treatment with MCC950 showed elevation in full-length mediator IL-1β in ileum and decreased level of cleaved IL-1β in spleen.