ABSTRACT
Surgical problems in children with Down syndrome include a wide range of multidisciplinary conditions such as congenital heart disease, gastrointestinal and musculoskeletal abnormalities. Cardiac anomalies such as atrioventricular septal defects (ASD), gastrointestinal anomalies such as duodenal atresia, orthopedic anomalies such as atlantoaxial instability and hip dysplasia, and potential malignancies should be specifically investigated and prepared by these departments in this disease group. Surgical departments such as cardiovascular and pediatric surgery and orthopedics, and internal departments including pediatric cardiology, gastroenterology and neonatology should adopt a multidisciplinary approach and patient follow-up should be meticulously carried out by all these departments. In the management of these problems, the unique needs of individuals with Down syndrome should be taken into consideration and holistic care strategies should be emphasized. In the content of the chapter, pediatric surgical techniques and treatment approaches that will improve the overall results, with a special emphasis on gastrointestinal problems for this special disease, will be examined and ongoing research will be reviewed.

Keywords: Down syndrome; general surgery; familial duodenal atresia; Hirschsprung disease