Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital

Erdol M. A., Tanacan A., Eroglu H., Tonyali N. V., Erdogan M., Yucel A., ...More

HYPERTENSION IN PREGNANCY, vol.40, no.3, pp.202-208, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1080/10641955.2021.1939712
  • Journal Name: HYPERTENSION IN PREGNANCY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.202-208
  • Keywords: NT-proBNP, chronic hypertension, pregnancy, perinatal outcome, NATRIURETIC PEPTIDE LEVELS, FETAL-GROWTH RESTRICTION, RISK-FACTORS, NT-PROBNP, PREECLAMPSIA, WOMEN, ECHOCARDIOGRAPHY, COMPLICATIONS, MANAGEMENT, ARTERY
  • Ankara University Affiliated: Yes

Abstract

Background This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT). Method 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated. Results NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04). Conclusion NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.