Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.11, sa.2, ss.150-154, 2000 (SCI-Expanded)
Background/aims: It has recently been established that gluten-sensitive enteropathy has a wide variety of clinical symptoms and that the disease can show a spectrum of histopathological lesions from flat mucosa of classic celiac disease to almost normal mucosa in some cases. Detailed histopathological typing is now required to show the range of mucosal lesions seen within the spectrum of gluten-sensitive enteropathy in small bowel biopsies from patients suspected of this disease. Methods: In the current study, Haemotoxylen and Eosin stained sections of 50 small bowel biopsies showing features consistent with the disease were assessed according to the following criteria: normal mucosa = Type 0 (pre-infiltrative lesion); intraepithelial lymphocytes infiltration in the villous epithelium of architecturally normal mucosa = Type 1 (infiltrative lesion); normal mucosa + crypt hyperplasia + intraepithelial lymphocytes infiltration in the epithelium = Type 2 (hyperplastic lesion) and flat mucosa + intraepithelial lymphocytes increase = Type 3 (destructive lesion). Age and sex distributions according to histopathological types were determined. Results: Gluten-sensitive enteropathy cases were typed according to the above criteria, with a significant number of both pediatric and adult patients showing type 1 or type 2 pathology. Conclusions: The results of this study emphasise the necessity and importance of histopathological typing in detecting cases lacking the features of classic celiac disease.