Early prediction of anthracycline induced cardiotoxicity

Erkus B., Demirtas S., Yarpuzlu A. A., Can M., Genc Y., Karaca L.

ACTA PAEDIATRICA, sa.4, ss.506-509, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1651-2227.2006.00174.x
  • Dergi Adı: ACTA PAEDIATRICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.506-509
  • Anahtar Kelimeler: antioxidant status, anthracyclines, brain natriuretic peptide, cardiac troponin, cardiotoxicity, CARDIAC TROPONIN-I, BRAIN NATRIURETIC PEPTIDE, HEART-FAILURE, FOLLOW-UP, CHILDREN, DOXORUBICIN, ENZYMES, MARKERS, ASSAY
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim: The purpose of this study is to evaluate echocardiographically determined cardiac functions with serum levels of brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and total antioxidant status (TAOS) in childhood leukemia treated with chemotherapeutics containing anthracyclines. Methods: A study group of 29 patients who have been followed for acute lymphoblastic leukemia (ALL) and administered a treatment protocol containing chemotherapy of anthracyclines were included in the analysis. Levels of BNP, cTnI and TAOS were studied in serum samples of the patients. Results: We demonstrated that as the drug dosage increased, systolic ejection fraction (EF) and shortening fraction (FS) values decreased (EF r(2) = 0.2327, FS r(2) = 0.251). On the other hand, increased dosage of anthracycline therapy was associated with significant raise in plasma BNP levels (r(2) = 0.246) and significant decrease in serum TAOS levels (r(2) = 0.317) without any change in serum cTnI levels. Conclusion: Our study suggest that serum TAOS and BNP levels may be useful as an early and sensitive indicator of anthracycline induced cardiotoxicity.