In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

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Yilmazer A., de Lazaro I., Bussy C., Kostarelos K.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, no.82, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2013
  • Doi Number: 10.3791/50837
  • Journal Name: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Stem Cell Biology, Issue 82, Pluripotent Stem Cells, Induced Pluripotent Stem Cells (iPSCs), Transcription Factors, General, Gene Therapy, Gene Expression, iPS, OKSM, regenerative medicine, STEM-CELLS, HUMAN FIBROBLASTS, GENERATION, MOUSE, EXPRESSION, VECTORS
  • Ankara University Affiliated: No

Abstract

Induced pluripotent stem (iPS) cells that result from the reprogramming of somatic cells to a pluripotent state by forced expression of defined factors are offering new opportunities for regenerative medicine. Such clinical applications of iPS cells have been limited so far, mainly due to the poor efficiency of the existing reprogramming methodologies and the risk of the generated iPS cells to form tumors upon implantation.