Obesity and left ventricular diastolic dysfunction

Berkalp B., Cesur V., Corapcioglu D., Erol Ç., Baskal N.

INTERNATIONAL JOURNAL OF CARDIOLOGY, vol.52, no.1, pp.23-26, 1995 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 1
  • Publication Date: 1995
  • Doi Number: 10.1016/0167-5273(95)02431-u
  • Journal Name: INTERNATIONAL JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.23-26
  • Keywords: obesity, relaxation, diastolic filling, SYSTOLIC FUNCTION, HYPERTENSION, DURATION
  • Ankara University Affiliated: Yes

Abstract

To assess the influence of obesity on left ventricular function, 20 obese women (mean body mass index (BMI) 33.8 +/- 3.1 kg/m(2) and mean age 31.1 +/- 2.4 years) without evidence of heart disease were evaluated by echocardiography, Obese subjects had greater left ventricular mass index (103 +/- 22 g/m(2), 76 +/- 18 g/m(2); P < 0.0001) and augmented fractional shortening (39 +/- 2.6%, 36 +/- 0.1%; P < 0,0001) than normals, Isovolumic relaxation time was prolonged in the obese group (92 +/- 11 ms) as compared with the control group (76 +/- 11 ms; P < 0.0001), The ratio of peak early and atrial filling velocities was significantly lower (1.2 +/- 0.4, 1.9 +/- 0.6; P < 0.0001) and atrial contribution was higher (39 +/- 9, 25 +/- 5; P < 0.0001) in obese subjects than in normals. Shortened deceleration time was measured in obese subjects (142 +/- 30, 179 +/- 20 ms; P < 0.0001). In conclusion, obesity causes relaxation and early filling abnormalities and diastolic filling is compensated by augmented atrial contribution. Diastolic dysfunction is an early indicator of cardiac involvement in obesity.