Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.56, sa.9, ss.621-625, 2006 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 9
- Basım Tarihi: 2006
- Doi Numarası: 10.1055/s-0031-1296762
- Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
- Sayfa Sayıları: ss.621-625
- Anahtar Kelimeler: antidiabetics, 2,4-thiazolidinediones, antidiabetic activities, synthesis, thiazole derivatives
- Ankara Üniversitesi Adresli: Evet
Özet
A series of thiazolyi-2,4-thiazolidinediones (Ia-f, IIa-f and IIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (4a-f) with chlorothiazolecarbaldehydes (2, 3a-b). The prepared compounds were tested for their insulinotropic activities in INS-1 cells.. A significant insulinotropic effect was seen with compounds If and IIa.