Relationship Between the Flow-Mediated Dilatation of the Human Brachial Artery and Blood Biomarkers Related to the Endothelial Function in Cardiovascular Diseases

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Usanmaz S. E., Atar I. A., Aksoyek A., Tola M., Kubatu E., Altuner T. K., ...More

ERCIYES MEDICAL JOURNAL, vol.43, no.1, pp.75-82, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.14744/etd.2020.90592
  • Journal Name: ERCIYES MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.75-82
  • Keywords: Flow-mediated dilatation, endothelial function, nitric oxide, ADMA, cardiovascular diseases, HYDROGEN-SULFIDE, DIMETHYLARGININE, DILATION, STRESS
  • Ankara University Affiliated: Yes

Abstract

Objective: Endothelial dysfunction plays an important role in the development of heart diseases. Although several markers have been examined, a definitive biomarker for monitoring endothelial function has not yet been established. The flow-mediated dilatation (FMD) of the brachial artery enables non-invasive assessment of endothelial function. This study investigated plasma levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), total antioxidant capacity (TAC), and hydrogen sulfide (H 2 S) as biomarkers of endothelial function. This study aimed to investigate any correlation between FMD and these blood biomarkers in patients with diabetes mellitus (DM), prediabetes (preDM), coronary artery disease (CAD), and valvular heart disease (VD).