Akademik Veri Yönetim Sistemi
Acta Anaesthesiologica Italica / Anaesthesia and Intensive Care in Italy, cilt.50, sa.3, ss.181-186, 1999 (Scopus)
The effects on myocardial performance of alfentanil, an opioid that has been used both as a sole anesthetic and in conjunction with other anesthetic, are not clearly known. Its in vitro effects on the contractility of isolated cardiac tissue have been determined in different animal species but no in vitro studies of its inotropic influence on human myocardium exist. Therefore, the purpose of this study was to investigate the direct inotropic influence of alfentanil on the contractility of isolated human atrial tissue. Atrial tissues were obtained from 16 patients undergoing coronary bypass surgery and the contractions of isolated atrial strips, stimulated electrically with a square-wave DC impulse at 1 ms duration and 1 Hz, were examined in an organ bath. Alfentanil caused a concentration-dependent depression of contractility in the isolated strips, which was completely attenuated by naloxane (10-5 M). This study, the first to demonstrate a concentration-dependent, negative inotropic effect of alfentanil in isolated human atrial muscle, could have important implications for its clinical application.