Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit

Aydemir C., Onay H., Oguz S. S., Ozdemir T. R., Erdeve O., Ozkinay F., ...More

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.24, no.9, pp.1124-1127, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 9
  • Publication Date: 2011
  • Doi Number: 10.3109/14767058.2010.536865
  • Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1124-1127
  • Keywords: Mannose-binding lectin, invasive fungal infection, preterm neonates, polymorphism, SUSCEPTIBILITY, ASSOCIATION, PHAGOCYTOSIS, DEFICIENCY, GENOTYPE, DISEASE, BIRTH, MBL
  • Ankara University Affiliated: Yes

Abstract

Objective. Preterm neonates are susceptible to infection due to a combination of sub-optimal immunity and increased exposure to invasive organisms. Invasive fungal infections are associated with significant morbidity and mortality among preterm infants cared for in the neonatal intensive care unit (NICU). Mannose-binding lectin (MBL) is a component of the innate immune system, which may be especially important in the neonatal setting. The objective of this study was to investigate the presence of any association between MBL gene polymorphism and nosocomial invasive fungal infection in preterm neonates.