Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones

Bozdag-Duendar O., Verspohl E. J., Das-Evcimen N., Kaup R. M., Bauer K., Sarikaya M., ...Daha Fazla

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.16, sa.14, ss.6747-6751, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 14
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.bmc.2008.05.059
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6747-6751
  • Anahtar Kelimeler: antidiabetic agents, flavone, 2,4-thiazolidinediones, flavonyl-2,4-thiazolidinediones, insulinotropic activity, aldose reductase inhibition, synthesis, ALDOSE REDUCTASE INHIBITORS, DIABETIC COMPLICATIONS, HYPOGLYCEMIC ACTIVITY, FLAVONE DERIVATIVES, POLYOL PATHWAY, THIAZOLIDINEDIONES, COMMUNICATION, PREVENTION, AGENTS, RATS
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6 mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%). (c) 2008 Elsevier Ltd. All rights reserved.