The role of time interval elimination on pain control of preterm infants by sucrose administration
European Journal of Clinical Pharmacology, vol.79, no.6, pp.841-848, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 79 Issue: 6
- Publication Date: 2023
- Doi Number: 10.1007/s00228-023-03496-2
- Journal Name: European Journal of Clinical Pharmacology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, Chimica, CINAHL, EMBASE, MEDLINE
- Page Numbers: pp.841-848
- Keywords: Pain, PIPP-R scoring, Preterm, Sucrose
- Ankara University Affiliated: Yes
Abstract
Purpose: The 2-min time interval of sucrose administration given before minor painful procedures in preterm infants is based on a few limited studies. We aimed to assess availability of sucrose analgesia in emergency states of minor procedural pain by eliminating the 2-min time interval prior to heel lance in preterm infants. The primary outcome was Premature Infants Pain Profile-Revised (PIPP-R) at 30 and 60 s. Methods: Healthy 69 preterms undergoing a heel lance, who were assigned randomly to 1 of 2 groups, i.e., group I, with the 2-min time interval of per oral 24% sucrose given prior to heel lance, or group II, without a time interval of per oral 24% sucrose, were recruited. Premature Infants Pain Profile-Revised, crying incidence, duration, and heart rate at 30 and 60 s following heel lance were the outcome measures in this single-center, randomized, prospective study. Results: The 2 groups did not differ significantly in PIPP-R scores at 30 s (6.63 vs. 6.32, p =.578) and 60 s (5.80 vs. 5.38, p =.478). The crying incidence was similar between the 2 groups (p =.276). The median crying duration was 6 s (range: 1–13 s) in group I and 4.5 s (range: 1–18 s) in group II (p =.226). No significant differences in the heart rates between the 2 groups and the proportion of adverse events by time interval elimination were recorded. Conclusions: Eliminating the time interval did not decrease the analgesic effect of orally administered 24% sucrose given prior to heel lance. In emergency states of minor procedural pain, eliminating the 2-min time interval following sucrose administration is safe and efficacious in preterm infants.