The role of time interval elimination on pain control of preterm infants by sucrose administration


Yaprak D., Karagöl B. S., Bozat A. D., KAR İ.

European Journal of Clinical Pharmacology, cilt.79, sa.6, ss.841-848, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00228-023-03496-2
  • Dergi Adı: European Journal of Clinical Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, Chimica, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.841-848
  • Anahtar Kelimeler: Pain, PIPP-R scoring, Preterm, Sucrose
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose: The 2-min time interval of sucrose administration given before minor painful procedures in preterm infants is based on a few limited studies. We aimed to assess availability of sucrose analgesia in emergency states of minor procedural pain by eliminating the 2-min time interval prior to heel lance in preterm infants. The primary outcome was Premature Infants Pain Profile-Revised (PIPP-R) at 30 and 60 s. Methods: Healthy 69 preterms undergoing a heel lance, who were assigned randomly to 1 of 2 groups, i.e., group I, with the 2-min time interval of per oral 24% sucrose given prior to heel lance, or group II, without a time interval of per oral 24% sucrose, were recruited. Premature Infants Pain Profile-Revised, crying incidence, duration, and heart rate at 30 and 60 s following heel lance were the outcome measures in this single-center, randomized, prospective study. Results: The 2 groups did not differ significantly in PIPP-R scores at 30 s (6.63 vs. 6.32, p =.578) and 60 s (5.80 vs. 5.38, p =.478). The crying incidence was similar between the 2 groups (p =.276). The median crying duration was 6 s (range: 1–13 s) in group I and 4.5 s (range: 1–18 s) in group II (p =.226). No significant differences in the heart rates between the 2 groups and the proportion of adverse events by time interval elimination were recorded. Conclusions: Eliminating the time interval did not decrease the analgesic effect of orally administered 24% sucrose given prior to heel lance. In emergency states of minor procedural pain, eliminating the 2-min time interval following sucrose administration is safe and efficacious in preterm infants.