Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization

Süzen S., Tekiner-Gulbas B., Shirinzadeh H., Uslu D., Gürer Orhan H., Gümüştaş M., ...Daha Fazla

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.28, sa.6, ss.1143-1155, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/14756366.2012.717223
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1143-1155
  • Anahtar Kelimeler: Indole, hydrazone/hydrazide, melatonin, synthesis, antioxidant activity, voltammetry, HYDRAZIDE/HYDRAZONE DERIVATIVES, 2-PHENYLINDOLE DERIVATIVES, ELECTROCHEMICAL-BEHAVIOR, PHARMACEUTICALS, METABOLISM, MECHANISMS, ELECTRODES, HYDRAZONES, OXIDATION, PATHWAYS
  • Ankara Üniversitesi Adresli: Evet

Özet

Melatonin (MLT) is a strong free-radical scavenger, which protects the body from the effects of oxidants. In recent years, MLT have been described resulting in much attention in the development of synthetic compounds possessing. As a part of our ongoing study a series of indole-based MLT analogue hydrazide/hydrazone derivatives were synthesized, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe. Membrane stabilizing effect of all compounds was also investigated by lactate dehydrogenase leakage assay. Furthermore voltammetric methods have been applied to the synthesized compounds to characterize oxidation potentials to get insight into their metabolism owing to the oxidation mechanisms taking place at the electrode and in the body share similar principles.