Atıf İçin Kopyala
Bozdag O., Verspohl E., Ertan R.
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.50, sa.6, ss.539-543, 2000 (SCI-Expanded)
-
Yayın Türü:
Makale / Tam Makale
-
Cilt numarası:
50
Sayı:
6
-
Basım Tarihi:
2000
-
Dergi Adı:
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
-
Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED)
-
Sayfa Sayıları:
ss.539-543
-
Anahtar Kelimeler:
antidiabetic agents, diabetes mellitus, insulin secretion, flavone derivatives, 2,4-thiazolidinediones, ALDOSE REDUCTASE, SUBSTITUTED THIAZOLIDINEDIONES, ANTIDIABETIC AGENTS, INSULIN-SECRETION, NIDDM, INHIBITION, CS-045, RAT
-
Ankara Üniversitesi Adresli:
Evet
Özet
A new series of 4'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized. Their chemical structures have been elucidated by IR,H-1-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1, 2, 6 and 7.