Synthesis and hypoglycemic activity of some new flavone derivatives - 2nd communication: 4 '-flavonyl-2,4-thiazolidinediones
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.50, sa.6, ss.539-543, 2000 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 6
- Basım Tarihi: 2000
- Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.539-543
- Anahtar Kelimeler: antidiabetic agents, diabetes mellitus, insulin secretion, flavone derivatives, 2,4-thiazolidinediones, ALDOSE REDUCTASE, SUBSTITUTED THIAZOLIDINEDIONES, ANTIDIABETIC AGENTS, INSULIN-SECRETION, NIDDM, INHIBITION, CS-045, RAT
- Ankara Üniversitesi Adresli: Evet
Özet
A new series of 4'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized. Their chemical structures have been elucidated by IR,H-1-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1, 2, 6 and 7.