Ursodeoxycholic acid treatment in isolated chronic graft-vs.-host disease of the liver

Arat M., Idilman R., Soydan E., Soykan I., Erden E., Karayalcin S., ...More

CLINICAL TRANSPLANTATION, vol.19, no.6, pp.798-803, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1399-0012.2005.00424.x
  • Journal Name: CLINICAL TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.798-803
  • Keywords: allogeneic hematopoietic cell transplantation, cholestatic liver diseases, chronic graft-vs.-host disease, ursodeoxycholic acid, PRIMARY BILIARY-CIRRHOSIS, STEM-CELL TRANSPLANTATION, HEPATOBILIARY DISORDERS, BONE-MARROW, MECHANISMS, THERAPY
  • Ankara University Affiliated: Yes

Abstract

Objectives: Data regarding the long-term treatment of ursodeoxycholic acid (UDCA) in individuals of chronic graft-vs.-host disease (cGVHD) of the liver are limited. The aims of this prospective study were to determine whether, (i) UDCA treatment is useful as a long-term treatment for individuals with limited cGVHD of the liver following allogeneic hematopoietic cell transplantation, and (ii) the tolerability of UDCA treatment in such individuals.