Research Information System
EXPERT REVIEW OF OPHTHALMOLOGY, no.3, pp.287-296, 2010 (ESCI)
Olopatadine topical ophthalmic solution is a potent antiallergic agent that has selective histamine H-1 - receptor antagonizing and mast cell-stabilizing activity. Olopatadine is available as a 0.1% formulation and, more recently, as a 0.2% formulation. The drug inhibits proinflammatory mast cell mediator release, specifically histamine, and the release of inflammatory lipid mediators such as leukotriene and thromboxane from human leukocytes and eosinophils. In preclinical and clinical studies, olopatadine has proven to be a safe, comfortable and effective medication for the treatment of seasonal and perennial allergic conjunctivitis. The drug effectively relieves itching, redness, chemosis, tearing and lid swelling related to ocular allergy, and is also helpful in the management of nasal allergic symptoms. This article will review the current literature on the safety and efficacy of olopatadine, and will discuss the role of olopatadine in treating ocular allergy.