Effects of N-butyl-2-cyanoacrylate on high-level jejunojejunostomy.

Ensari C., GENÇ V., ÇAKMAK A., Erkek B., Karayalcin K.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, cilt.44, sa.1, ss.13-6, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1159/000257969
  • Dergi Adı: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.13-6
  • Anahtar Kelimeler: N-butyl-2-cyanoacrylate, Anastomosis, Burst pressure, Adhesions, COLONIC ANASTOMOSES, REPERFUSION INJURY, INTESTINAL ANASTOMOSIS, ABDOMINAL-SURGERY, TISSUE ADHESIVE, HIGH-RISK, CYANOACRYLATE, GLUE, RAT, ISCHEMIA
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Morbidity and mortality due to anastomotic complications in gastrointestinal surgery remain important problems. The tissue adhesive N-butyl-2-cyanoacrylate (NB2CA) is used in many fields of surgery. This study was designed to assess the effects of NB2CA on high-level jejunojejunostomy. Materials and Methods: Forty male albino Wistar rats were divided into 4 groups of 10 each. The groups were treated as follows: group 1 underwent only a jejunojejunostomy, group 2 underwent jejunojejunostomy followed by NB2CA application around the anastomosis, group 3 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion, and group 4 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion followed by NB2CA application around the anastomosis. At postoperative day 7, the subjects in all groups were sacrificed. Intra-abdominal adhesions, anastomotic complications and anastomotic burst pressures (ABP) were recorded. Results: The analysis of all the groups for adhesion scores and ABP showed statistical significance (p < 0.001). Conclusions: The use of NB2CA had positive effects in terms of increasing ABP both with and without the initial ischemia- reperfusion insult. However, it had the adverse effect of significantly increasing the number of intra-abdominal adhesions. © 2009 S. Karger AG, Basel.