The role of thrombofilia related to factor V Leiden and Factor II G20210A mutations in recurrent abortions

Aksoy M., Tek I., KARABULUT H. G., BERKER B., Soylemez F.

Journal of the Pakistan Medical Association, cilt.55, sa.3, ss.104-108, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 3
  • Basım Tarihi: 2005
  • Dergi Adı: Journal of the Pakistan Medical Association
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.104-108
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: To study, the impact of thrombophilia caused by Factor V, Factor II G20210A mutations on recurrent abortions, the prevelance of Factor V Leiden and Factor II G20210A mutation in patients with habitual abortions. Medhods: Forty one patients with a diagnosis of habitual abortion were enrolled in the study. Control group consisted of 50 women without a history of poor obstetric outcome. 10 ml. peripheral venous blood was taken from study and control groups and transferred to EDTA tubes, and were tested for Factor V Leiden and Factor II G20210A mutations by PCR in genetics laboratory. Results: Phenotypes of 91 cases were determined by PCR for Factor V Leiden. It was established that of 41 patients in the study group, 31 (75.6%) had GG genotype, 9 (22%) had GA genotype and 1 (2.4%) had A A genotype. In the control group, 45 (90%)of 50 women had GG genotype and 5 (10%) had GA genotype. A allele carrier status was found to be 24.4% in study group and 10% in the control group. The difference between them was not statistically significant (p=0.06). Conclusions: The results obtained from patients and control group have no difference in Factor V Leiden and Factor II G20210A mutations. These results suggest that mutations have no role in etiology of 1. and 2. trimester recurrent abortions.