Erythrocyte nitric oxide metabolism in patients with chronic renal failure

Durak I., ÖZTÜRK H. S., ELGÜN ÜLKAR S., Cimen M., Yalcin S.

CLINICAL NEPHROLOGY, vol.55, no.6, pp.460-464, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 6
  • Publication Date: 2001
  • Journal Name: CLINICAL NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.460-464
  • Keywords: nitric oxide synthase, arginase, chronic renal failure, L-ARGININE, GLOMERULAR INJURY, BLOOD-PRESSURE, HYPERTENSION, INHIBITOR, KIDNEY, HEMODYNAMICS, ACCUMULATION, DISEASE, RATS
  • Ankara University Affiliated: Yes

Abstract

Aims: This study aims to investigate arginine-nitric oxide pathway in chronic renal failure (CRF) and to establish erythrocyte nitric oxide synthase (NOS) and arginase (ARG) activities in patients wit CRF. Materials and methods: NOS and ARG activities were measured in erythrocytes from 30 patients with CRF and 12 control subjects. Results: Erythrocyte NOS activity was found to be significantly lower and ARG activity higher in patients with CRF compared with controls. No differences were, however, found between patients with and without hemodialysis. A negative correlation (r = -0.7) was established between ARG and NOS activities in erythrocytes from patients. Conclusions: Results suggest that erythrocyte NO production is diminished in patients with CRE, possibly due to decreased NOS and increased ARG activities.