NH2-fMWCNT-titanium dioxide nanocomposite based electrochemical sensor for the voltammetric assay of antibiotic drug nadifloxacin and its in vitro permeation study
Journal of Electroanalytical Chemistry, cilt.859, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 859
- Basım Tarihi: 2020
- Doi Numarası: 10.1016/j.jelechem.2020.113857
- Dergi Adı: Journal of Electroanalytical Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
- Anahtar Kelimeler: Nadifloxacin, Nanosensor, Multiwalled carbon nanotubes, TiO2 nanoparticles, Cream formulations, In vitro permeation study, WALLED CARBON NANOTUBES, REDUCED GRAPHENE OXIDE, MODIFIED ELECTRODES, FLUFENAMIC ACID, ASCORBIC-ACID, URIC-ACID, NANOPARTICLES, CHITOSAN, NANOSENSOR, REMOVAL
- Ankara Üniversitesi Adresli: Evet
Özet
© 2020An electrochemical sensor is described for the determination of nadifloxacin (NF). A glassy carbon electrode (GCE) was modified with amino-functionalized multiwalled carbon nanotubes and titanium dioxide nanoparticles. The modified GCE was characterized by electrochemical impedance spectroscopy, cyclic voltammetry and scanning electron microscopy. The electro-oxidation of NF follows a pH-dependent irreversible behavior. The effects of pH value, scan rate, supporting electrolyte, accumulation potential and accumulation time were optimized. Under optimum conditions and at a typical working potential of 600 mV (vs. Ag/AgCl), the adsorptive stripping voltammetric response is linear in the 5 nM to 5.0 μM NF concentration range. The limit of detection is 1.69 × 10−10 M in acidic solution of pH 1. The selectivity was investigated in the presence of 1–1000-fold concentrations of potentially interfering agents. Recoveries from cream formulations spiked with NF were performed to study precision and accuracy.