Akademik Veri Yönetim Sistemi
Turkish Journal of Pharmaceutical Sciences, cilt.12, sa.2, ss.147-156, 2015 (Scopus)
© 2015, Turkish Pharmacists Association. All rights reserved.In this study, the quantitative amounts of chlorogenic acid (CA) in spray dried artichoke (Cynara scolymus L.) leaf extract (SD) and standardized artichoke commercial products (CP1, CP2) were calculated by using HPLC. The amounts of CA were 4.66±2.96x10-3 mg/capsule and 27.9±9.98x10-3mg/capsule for CP1 and CP2 respectively. The in vitro phytoequivalance of SD, CP1 and CP2 were evaluated by using the content uniformity, in vitro dissolution and disintegration tests. A complete CA release was observed in all formulations which correspond to almost 25 mg for CP2 and 5 mg for SD and CP1. CA was released in a delayed manner from CP2 formulation. This result is compatible with the disintegration results indicating the slow disruption of the gelatin capsule in CP2 formulation. The time recorded for the disintegration of CP1, CP2 and SD were 10.97±0.64, 57.25±1.56 and 6±0.30 minute respectively. The results of the present work indicate that CA in commercial products was present but with amounts less than required to be contained in a capsule. Also these commercial products have different chromatographic profiles. So this study revealed that some artichoke extracts which are standardized as CA, were not phytoequivalent.