Prevention by a carbacyclin analogue (ZK 36 374) of digoxin-induced ventricular extrasystoles in guinea-pig myocardium

Metin M., Dörtlemez Ö., AKAR F., Ercan Z., Türker R.

European Journal of Pharmacology, vol.98, no.1, pp.125-128, 1984 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 1
  • Publication Date: 1984
  • Doi Number: 10.1016/0014-2999(84)90117-1
  • Journal Name: European Journal of Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.125-128
  • Keywords: Digoxin, P-R intervel, Venticular extrasystoles, ZK 36 374
  • Ankara University Affiliated: Yes

Abstract

Intravenous infusion of ZK 36 374 to the anesthized guinea-pig or addition of the compound to the perfusion medium of the isolated perfused guinea-pig heart prevented digoxin-induced ventricular premature beats without altering the prolongation of the P-R interval by the glycoside. The prevention by ZK 36 374 of the ventricular extrasystoles induced by digoxin was obtained at lower concentrations while higher doses of the compound produced a dysrhythmic effect which terminated within a few min after the cessation of drug application. © 1984.