Alterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus

Inanc M., Kiziltoprak H., Hekimoglu R., Tekin K., Ozalkak S., Koc M., ...Daha Fazla

OCULAR IMMUNOLOGY AND INFLAMMATION, cilt.28, sa.3, ss.362-369, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/09273948.2019.1571212
  • Dergi Adı: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.362-369
  • Anahtar Kelimeler: mellitus, dry eye, impression cytology, ocular surface, tear film, EPITHELIAL BARRIER FUNCTION, DRY EYE, FLUORESCEIN, TIME, RELIABILITY, SYMPTOMS, DISEASE, BREAKUP
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose: To investigate whether diabetes mellitus (DM) affects ocular surface of children with well-controlled type 1 DM. Methods: Sixty-five diabetic patients and 55 age-matched controls enrolled to study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, tear film break-up time (TBUT) analysis, Schirmer test, and conjunctival impression cytologic analysis were performed. Results: Schirmer test and TBUT results were significantly lower in DM group than controls (p = 0.001, for all). OSDI scores of all participants were within normal range. Impression cytology analysis showed grade 0 changes in all participants and there was no difference between groups for goblet cell density (p > 0.05). The TBUT results were significantly associated with duration of DM (r = -0.309, p = 0.036). Conclusion: Diabetic children without symptoms, signs, and definite diagnosis of dry eye still had lower TBUT and Schirmer test results than controls; however, impression cytology analysis was similar in both groups.