Akademik Veri Yönetim Sistemi
Istanbul Journal of Pharmacy, cilt.51, sa.3, ss.326-332, 2021 (ESCI)
Background and Aims: Ballota is represented by 12 species and 16 taxa in Turkey. Eleven of the 16 taxa are endemic to Tur-key. Ballota have been used in different treatments in folk medicine. Anti-inflammatory drugs act by protecting lysosomal membrane integrity or inhibiting enzymes of prostaglandins and thromboxane inflammatory mediators synthesized by de-activating of cyclooxygenase (COX), COX-1 and COX-2 enzymes. Besides, degradation of lysosomal membrane brings on the release inflammatory mediators so human red blood cells (HRBC) can be used for evaluating of anti-inflammatory activity. One of the treatment approaches of diabetes mellitus is alpha-glucosidase enzyme inhibition. These enzymes play an important role in glucose releasing from carbohydrates. Due to the adverse effects of synthetic drugs, natural alpha-glucosidase inhibitors have been discussed as therapeutic agents to manage diabetes mellitus. In the light of the traditional use of Ballota species, we aimed to investigate the anti-inflammatory and anti-diabetic activities of the ethanol and aqueous extracts from the aerial parts of 14 Ballota taxa.