Effects of plasma nitric oxide levels on platelet activation in single donor apheresis and random donor concentrates

Buyukkagnici D. I., Ilhan O., Kavas G. O., Arslan O., Arat M., Dalva K., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.36, sa.1, ss.73-78, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.transci.2006.05.016
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-78
  • Anahtar Kelimeler: platelet, platelet apheresis, platelet activation, P-selectin, nitric oxide, P-SELECTIN EXPRESSION, IN-VIVO, ARTERIAL THROMBOSIS, STORAGE LESION, FREE-RADICALS, INFARCTION, APOPTOSIS, RELEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

P-selectin is an useful marker to determine platelet activation and nitric oxide inhibits platelet activation, secretion, adhesion and aggregation. The aim of this study was to investigate the relationship between nitric oxide and P-selectin values in both single donor apheresis and random donor platelet concentrates. According to the results of this study, we found that the best platelet concentrate is freshly prepared single donor apheresis concentrate and it is important to prevent activation at the beginning of the donation. Nitric oxide, which is synthesized from platelets during the storage period, is not sufficient to prevent platelet activation. (c) 2006 Published by Elsevier Ltd.