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Turk Anesteziyoloji ve Reanimasyon, vol.31, no.3, pp.110-115, 2003 (Scopus)
In this study, we aimed to compare perioperative supplemental oxygen with dexamethasone and ondansetron to prevent postoperative nausea and vomiting (PONV) in patients undergoing middle ear surgery. Sixt two patients undergoing elective middle ear surgery, between]8 and 60 years (ASAI-II), were included in the study. Patients were randomly assigned to 4 groups: for Group K (control group) and Group AO (supplemental oxygen no antiemetic medication was used. After induction, 8 mg ondansetron for Group O (prophylactic ondansetron group) and 5 mg dexamethasone for Group D (prophylactic dexamethasone group) were administered for prophylaxis. In Group AO 25 % nitrous oxide and 75 % oxygen, in other groups 50% nitrous oxide and 50% oxygen were alpplied for maintenance. Postoperative nausea and vomiting, atiemetic drug usage and other complications were recorded. The incidence of postoperative nausea and vomiting for the first six hours aws 86% and 60% in Group K, 50% and 23% in group O, 53% and 26% in group D, 43% and 37% in group AO. Need for the antiemetic drugs in group 0, group D and group AO was significantly lower than group K. No side effect and pulmonary complication were observed in all groups. We concluded that the supplemental oxygen is as effective as dexamethasone and ondansetron for prevention of postoperative nause and vomiting and diminishes the need for rescue antiemetic.