Magnesium sulfate treatment decreases caspase-3 activity after experimental spinal cord injury in rats

Solaroglu I., Kaptanoglu E., Okutan O., Beskonakli E., Attar A., Kilinc K.

SURGICAL NEUROLOGY, cilt.64, ss.17-21, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.surneu.2005.07.058
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.17-21
  • Anahtar Kelimeler: spinal cord injury, magnesium, apoptosis, caspase, methylprednisolone, APOPTOTIC CELL-DEATH, IMPROVES FUNCTIONAL RECOVERY, D-ASPARTATE RECEPTOR, LIPID-PEROXIDATION, NITRIC-OXIDE, ULTRASTRUCTURAL FINDINGS, ACTIVATED CASPASE-3, CONTROLLED TRIAL, BRAIN INJURY, LONG-TERM
  • Ankara Üniversitesi Adresli: Hayır

Özet

Background: Apoptosis has increasingly been considered as an important factor in secondary injury after spinal cord injury (SCI). Manifestation of apoptotic cell death process involves activation of the caspase-3 apoptotic cascade. The aim of the study was to demonstrate the effect of magnesium sulfate on caspase-3 activity and to compare its effectiveness with methylprednisolone after acute SCI.