Effects of TAM RTKs on Signaling Pathways in Hematological Malignancies “Tyrosine Kinase: Molecular Activation and Signal Transduction in Health and Disease
Advances in Health and Disease, Lowell T. Duncan, Editör, Nova Science Publishers, Inc, New York, ss.93-115, 2026
- Yayın Türü: Kitapta Bölüm / Mesleki Kitap
- Basım Tarihi: 2026
- Doi Numarası: 10.52305/jyfj1504
- Yayınevi: Nova Science Publishers, Inc
- Basıldığı Şehir: New York
- Sayfa Sayıları: ss.93-115
- Editörler: Lowell T. Duncan, Editör
- Ankara Üniversitesi Adresli: Evet
Özet
The immune response is normally crucial for maintaining tissue integrity and preventing malignant transformation. However, persistent immune system dysfunction triggered by chronic inflammation, long-term viral or bacterial infections, and continuous tissue damage can create a microenvironment that promotes abnormal cell survival and tumor development.
The Tyro3-Axl-Mertk (TAM) Receptor Tyrosine Kinases (RTK), normally play a vital role in immune response generation and inflammation resolution. However, under tumor conditions, overexpression or ectopic expression of these molecules stimulates signaling pathways, contributing to tumor development. They may downregulate a signaling pathway or promote cancer cell survival, and they may activate specific genes, promoting cell proliferation.
At this point, a complete understanding of the mechanism of these molecules in the signaling pathway is becoming crucial in the development of new treatments. Methods such as blocking these molecules or selectively removing them from the blood can contribute to the development of new treatment options. In this section, we tried to describe the mechanism of the TAM RTK and signalling pathways interaction in hematological malignancies.