Akademik Veri Yönetim Sistemi
Turkish Journal of Pharmaceutical Sciences, cilt.4, sa.1, ss.41-52, 2007 (SCI-Expanded)
In this study, the effects of type and ratio of the polymers [hydroxypropylmethylcellulose (Methocel® K100LV and K15M), methacrylic acid copolymer (Eudragit® L100)] and direct compression agents (Pharmatose DCL11®, Cellactose® 80, Microcel® PH101) on the extended release of atenolol from hydrophilic matrix tablets prepared by direct compression method were investigated. Spectrophotometric method used for the determination of atenolol in dissolution media was validated by calculating linearity and range, precision, accuracy and specificity values. The dissolution profiles showed that hydroxypropylmethylcellulose ratio and type play a significant role in drug release and direct compression agents (lactose or cellulose based) can be effective on drug release at the presence of low amounts of hydroxypropylmethylcellulose in the formulations. It is also observed that methacrylic acid copolymer could not effectively hinder the drug release in acidic medium and binary mixtures of polymers could lead to discontinuous drug release profiles. Results indicated that low viscosity grade hydroxypropylmethylcellulose can be preferred to obtain linear drug release profiles for a duration of eight hours with a lactose-based direct compression agent. Results of kinetic data indicated that atenolol release from the formulations generally fits best to the Korsmeyer-Peppas kinetic model and drug release mechanism shows non-Fickian transport mechanism according to the values of diffusion exponent.