The effects of sulphasalazine on urinary excretion of the hydroxypyridinium crosslinks of collagen in patients with rheumatoid arthritis

Dilek K., Ali I., Goksal K., Huseyin T., Guner T.

YONSEI MEDICAL JOURNAL, vol.43, no.4, pp.435-440, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.3349/ymj.2002.43.4.435
  • Journal Name: YONSEI MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.435-440
  • Keywords: pyridinium crosslinks, sulphasalazine, rheumatoid arthritis, DISEASE-ACTIVITY, JOINT DAMAGE, BONE, LINKS, MARKERS, OSTEOARTHRITIS, OSTEOPOROSIS, PYRIDINOLINE, DEGRADATION, DENSITY
  • Ankara University Affiliated: No

Abstract

Secondary osteoporosis is a feature of rheumatoid arthritis (RA). In recent years, several attempts have been made to develop specific markers for monitoring connective tissue metabolism in arthritic diseases. Our purpose, in this study was to assess pyridinium crosslinks (PYD and DPYD) excretion in relation to the activity of RA (changes related to sulphasalazine treatment).