Moclobemide and sertraline in the treatment of melancholic and nonmelancholic major depression: A comparative study

Turkcapar M., Orsel S., Iscan E., Akdemir A., Kilic E., Ozbay M.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, vol.13, no.1, pp.21-27, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 1998
  • Journal Name: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.21-27
  • Keywords: depression treatment, melancholic depression, nonmelancholic depression, sertraline, moclobemide, ENDOGENOUS-DEPRESSION
  • Ankara University Affiliated: No

Abstract

The objectives of this study were first to compare the responses to moclobemide and sertraline in melancholic and nonmelancholic major depressive patients and secondly to compare the responses of melancholic and nonmelancholic patients in general. Sixty-three patients, with diagnosis of major depression according to the DSM-III-R criteria were included in the study. In this single blind, comparative, randomized study, 29 patients were treated with moclobemide and 34 patients were treated with sertraline for 13 weeks. A 50 per cent decrease of the HDRS (Hamilton Depression Rating Scale) is defined as response.