An Unusual Case of Acute Kidney Injury with AA Amyloidosis

EREN SADİOĞLU R., KİREMİTCİ S., KUTLAY S., ŞENGÜL Ş.

TURKISH JOURNAL OF NEPHROLOGY, cilt.29, sa.3, ss.247-249, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5152/turkjnephrol.2020.4061
  • Dergi Adı: TURKISH JOURNAL OF NEPHROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.247-249
  • Anahtar Kelimeler: Acute kidney injury, amyloidosis, immunoglobulin G4-related disease, tubulointerstital nephritis
  • Ankara Üniversitesi Adresli: Evet

Özet

Acute kidney injury (AKI) is an initial clinical diagnosis in patients with rapid renal function deterioration. Underlying etiologies of AKI include primary kidney diseases, such as acute glomerular and vasculitic diseases, tubulointerstitial nephritis (TIN); systemic insults, such as ischemia and toxins; and obstructive nephropathy. Acute TIN is a common cause of AKI and may be caused by systemic autoimmune conditions, such as immunoglobulin G4-related diseases (IgG4-RD). To date, only one case demonstrates the association of IgG4-RD and AA amyloidosis. Here we report an IgG4-related TIN (IgG4-TIN) and AA amyloidosis in a patient who presented with gross hematuria, proteinuria, and AKI. IgG4-TIN should be considered as a potential cause of AKI as well as chronic kidney disease regarding its long-term inflammatory effects on the kidney.