Paraoxonase Activity Might be Predictive of the Severity of Aortic Valve Stenosis

Cagirci G., Cay S., Karakurt O., Durmaz T., YAZIHAN N., Canga A., ...Daha Fazla

JOURNAL OF HEART VALVE DISEASE, cilt.19, sa.4, ss.453-458, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2010
  • Dergi Adı: JOURNAL OF HEART VALVE DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.453-458
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and aim of the study: Aortic valve stenosis (AS) is the most common valvular heart disease in the western world, and in adults is invariably caused by the calcification of a normal tricuspid or congenital bicuspid valve. Calcific AS, as an active disease process, is characterized by lipid accumulation, inflammation and calcification that mimic atherosclerosis. Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-bound enzyme that exerts anti-atherogenic properties by protecting low-density lipoprotein (LDL)-cholesterol from oxidative modification. The study aim was to examine the association between PON-1 activity and AS.