Paraoxonase Activity Might be Predictive of the Severity of Aortic Valve Stenosis
JOURNAL OF HEART VALVE DISEASE, vol.19, no.4, pp.453-458, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 4
- Publication Date: 2010
- Journal Name: JOURNAL OF HEART VALVE DISEASE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.453-458
- Ankara University Affiliated: Yes
Abstract
Background and aim of the study: Aortic valve stenosis (AS) is the most common valvular heart disease in the western world, and in adults is invariably caused by the calcification of a normal tricuspid or congenital bicuspid valve. Calcific AS, as an active disease process, is characterized by lipid accumulation, inflammation and calcification that mimic atherosclerosis. Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-bound enzyme that exerts anti-atherogenic properties by protecting low-density lipoprotein (LDL)-cholesterol from oxidative modification. The study aim was to examine the association between PON-1 activity and AS.